These concepts provide new opportunities for monotherapy with novel conformation-selective drugs. The pooled effect estimates showed that combination therapy was associated with a significantly better immediate 1-month response rate than desmopressin monotherapy. Combination refers to the risk of drug treatment discontinuation in patients initially treated with drug combinations, … Such three-drug combination therapy was associated with lower mortality than was monotherapy (OR 3.86, 95% CI 1.60–9.32, P = 0.003, Fig. Author information: (1)Section of Inflammatory Diseases, Saint Mary's Hospital, Waterbury, Connecticut. A recently published trial 5 showed a non-inferiority of beta-lactam monotherapy vs. combination therapy in adults with CAP but patients had a mild disease (median CURB-65 score of 1) and the fact that intensive care admission was an exclusion criterion. Several studies have ques-tioned the clinical superiority of combination therapy and have addressed the issues of the increased toxicity and the increased cost related to combination treatment regimens [9–13]. Aims: Guidelines support use of drug combinations in most hypertensive patients, and recently treatment initiation with two drugs has been also recommended. Hypertension Update: Amlodipine and Atenolol: Combination Therapy Versus Monotherapy for blood pressure Management . The available clinical data comparing antibiotic combination with monotherapy come from studies with a number of major differences in design and analysis that make it difficult to interpret relative efficacy. The numbers of included participants and, hence the number of events, were too small to draw any conclusion about the relative efficacy of monotherapy versus combination therapy as initial treatment for primary hypertension. individuals experiencing adverse events with monotherapy versus combination therapy overall and by system (Table 1). The difference in the proportion of subjects discontinuing medication use because of adverse events in the combined therapy group was approximately twofold that of the mono-therapy group, but not statistically significant. Monotherapy, or the use of a single therapy, can be applied to any therapeutic approach, but it is most commonly used to describe the use of a single medication. We searched the PubMed and Scopus databases for studies reporting on the clinical outcomes of patients infected with MDR, XDR, and PDR Acinetobacter spp. We aimed to establish whether lithium plus valproate was better than monotherapy with either drug alone for relapse prevention in bipolar I disorder. combination therapy can be reserved for cases of treat-ment failure or resistance. Olmesartan-based monotherapy vs combination therapy in hypertension: A meta-analysis based on age and chronic kidney disease status. HYPOTHYROIDISM MONOTHERAPY VS COMBINATION THERAPY 5 addition to LT4. Government Medical College & Sassoon General Hospital, Pune, Maharashtra, India Monotherapy Versus Combination Therapy Approaches in Melanoma. In general, risks for overall treatment failure were significantly lower among patients on combination therapy compared to monotherapy users, with absolute risks for treatment failure being 1–22.3% percentage points lower compared to lithium monotherapy . This economic evaluation of combination treatment vs ipilimumab monotherapy demonstrates 3 important findings. Subgroup analysis showed a greater immediate 1-month response rate among desmopressin … Monotherapy vs combination therapy: safety. Memantine monotherapy was associated with a 7% lower risk for any cardiovascular event compared with both acetylcholinesterase inhibitor monotherapy and combination therapy, according to a new study. Rysz J(1)(2), Gluba-Brzózka A(1)(2), Franczyk B(1), Banach M(3)(2), Bartnicki P(1). combination therapy vs. monotherapy in the treatment of Gram-negative and Gram-positive bacterial infections. Show more. Monotherapy with a biologic DMARD might reasonably be presumed to have a better safety profile than combination with MTX or other csDMARD. Overall study drug discontinuations due to adverse events occurred more frequently in the amlodipine monotherapy group than in the amlodipine/valsartan combination therapy group (9 (3.1%) vs … Combination Therapy vs. Monotherapy. The type of definitive therapy (combination therapy versus monotherapy) did not significantly affect mortality; neither did the type of combination drug (aminoglycoside or quinolone) or type of backbone β-lactam (cephalosporin, penicillin or carbapenem) (Table 3). February 8, 2017. Compared with tumor necrosis factor inhibitor (TNFi) monotherapy, combination therapy with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) may not improve disease activity, but may improve drug survival, in psoriatic arthritis (PsA), according to study results published in The Journal of Rheumatology. To compare the clinical success and infliximab consumption of combination vs optimised monotherapy strategies. Improvements in symptom scores were greater in the combination-therapy group versus the doxazosin (P = 0.006) and finasteride monotherapy (P < 0.001) groups. Since multiple factors contribute to … The retinoids are the major biologic response modifiers used in CTCL, producing good response rates but … Double Covid-19 variant infection . A recently published trial 5 showed a non-inferiority of beta-lactam monotherapy vs. combination therapy in adults with CAP but patients had a mild disease (median CURB-65 score of 1) and the fact that intensive care admission was an exclusion criterion. Patients (N=140) admitted to the Ohio … Monotherapy with a biologic DMARD might reasonably be presumed to have a better safety profile than combination with MTX or other csDMARD. A higher percentage of patients with a history of intravenous (IV) drug use was observed in the combination therapy group vs the monotherapy group (58% vs 36%; P = .01). Initial combination therapy of dapagliflozin and metformin has been shown to be more effective in HbA 1c reduction versus dapagliflozin monotherapy or metformin monotherapy . Uncomplicated MRSA bacteremia was observed in 5% of patients in the combination therapy group and 1% in the monotherapy group. The use of combination antihypertensive agents as initial therapy has increased since 2003. EP. Twenty-nine patients (22.1%) treated with combination therapy and 41 patients (30.6%) treated with monotherapy experienced > or =1 adverse event considered possibly related to study drug. by the inclusion of 2212 patients who used monotherapy or FD two-drug combination therapy in different subperiods of the follow-up year and experienced at least one CV outcome, are shown in Figure 2. The difference in the proportion of subjects discontinuing medication use because of adverse events in the combined therapy group was approximately twofold that of the mono-therapy group, but not statistically significant. Methods: Electronic databases were searched for BP-lowering RCTs that compared combination treatment or monotherapy vs. placebo, no-treatment or less-complex treatment. 2–7 One in vitro time–kill experiment showed no single drug … mpler treatment regimens, using data from randomized clinical trials (RCTs). Monotherapy or the administration of a sole anticancer drug is still a clinical standard in cancer therapy; however, these treatment options are often deemed less effective than combinational therapy. A higher percentage of patients with a history of intravenous (IV) drug use was observed in the combination therapy group vs the monotherapy group (58% vs 36%; P = .01). Download : Download high-res image (376KB) Download : Download full-size image; Fig. Deedwania P(1), Weber M(2), Reimitz PE(3), Bakris G(4). Combination therapy with remdesivir and chloroquine exhibited a significant 2-log 10 reduction in live viral load (P < 0.05), which was similar to remdesivir monotherapy, indicating that the antiviral effect of this combination was largely due to remdesivir, without drug synergism. Contrast to monotherapy. highlights the various clinical trials done to compare monotherapy versus combination therapy. Another trial investigated triple therapy with obinutuzumab, ibrutinib, and venetoclax in 25 treatment-naïve CLL patients. Studies have demonstrated treatment failures and resistance development with monotherapy (MT); however, clinical data are limited with combination therapy (CT). In the long term treatment of bipolar disorder, in patients responding acutely to the addition of quetiapine to lithium or valproate, this combination reduces the subsequent risk of relapse to depression, mania or mixed states compared to monotherapy … Listing a study does not mean it has been evaluated by the U.S. Federal Government. In addition, monotherapy is relatively nontoxic and possibly less costly than combination therapy. Controversy surrounds combination treatment or monotherapy against multidrug-resistant (MDR), extensively drug-resistant (XDR), and pandrug-resistant (PDR) Acinetobacter infections in clinical practice. Monotherapy is a type of treatment which uses a single agent drug acting in a particular way for treatment. EP. Treatment of nosocomial pneumonia: monotherapy versus combination therapy. Bivariate unadjusted analyses compared clinical outcomes by monotherapy versus combination therapy. Eur Heart J. A total of 200 patients were included in the study. Objective: To compare the efficacy and adverse drug reactions of monotherapy and combination therapy of antihypertensive drugs in diabetic hypertensive patients.Methods: A prospective observational study of 18 months duration was conducted in the Department of Medicine of a tertiary care hospital in South India. “This may change the way we treat patients in the future,” said Barrientos. The more effective monotherapy, identified by renin profiling or sequential comparison of the 2 drugs, reduced systolic blood pressure, on average, by 5 mm Hg less than initial combination therapy. What Are the Clinical Implications? Initial combination therapy can be recommended for the treatment of blood pressure levels >150/95 mm Hg. Combination Therapy Versus Monotherapy in Reducing Blood Pressure: Meta-analysis on 11,000 Participants from 42 Trials ... from different classes is approximately 5 times more effective in lowering blood pressure than increasing the dose of 1 drug. Monotherapy shows the risk of discontinuation of antihypertensive drug treatment according to the class of antihypertensive drugs used as initial monotherapy. Combination drug versus monotherapy for the treatment of autosomal dominant polycystic kidney disease Expert Opin Pharmacother . Author information: (1)a Department of Nephrology, Hypertension and Family Medicine , Medical University of Lodz , Lodz , Poland. Monotherapy (grey), combination (orange), with the strength of the biological process denoted by radial distance. Several studies have ques-tioned the clinical superiority of combination therapy and have addressed the issues of the increased toxicity and the increased cost related to combination treatment regimens [9–13]. approved by the US FDA for the treatment of drug-resistant This article reviews the rationale and evidence for current recom- pneumococcal pneumonia. immunotherapy drug therapy combination clinical trials as topic special-feature unlocked special-property ... COTEZO IMblaze 370 was a three-arm randomized phase III study of atezolizumab plus cobimetinib versus atezolizumab monotherapy versus regorafenib in patients with previously treated metastatic colorectal cancer. Polymyxin monotherapy versus combination therapy, all-cause mortality by infection type. Monotherapy, or the use of a single therapy, can be applied to any therapeutic approach, but it is most commonly used to describe the use of a single medication. individuals experiencing adverse events with monotherapy versus combination therapy overall and by system (Table 1). Greco T(1). Many patients with hypertension require 2 or more drug classes to achieve their blood pressure (BP) goal. 2. To Compare the Efficacy of Combination Therapy vs Monotherapy for Pulmonary Arterial Hypertension in Systemic Sclerosis (BosSilSS) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Methods We studied the clinical success and infliximab consumption of both strategies in 149 patients (94 Crohn's disease; 55 ulcerative colitis) starting infliximab and undergoing intensive drug monitoring assisted treatment optimisation. Compared with zidovudine monotherapy, combination therapy with ... A triple-drug combination ... Saquinavir (Invirase) vs. hivid (Zalcitabine) vs. combination as treatment … Combination therapy should be favoured where possible, in accordance with EULAR guidance. We compared antihypertensive medication treatment patterns and BP control between patients who initiated combination therapy versus monotherapy. Methods: This retrospective cohort study included microbiology, clinical, and pharmacy data from all patients hospitalized between 2012 and 2018 at any Veterans’ Affairs medical center who had cultures that grew XDR Acinetobacter spp. There is insufficient evidence supporting improved efficacy of combination drug therapy vs monotherapy in the management of low back pain … And infliximab consumption of combination treatment vs ipilimumab monotherapy demonstrates 3 important findings Family Medicine, Medical University of,. Therapy in EGFR- or ALK-Mutated NSCLC optimised monotherapy Strategies infliximab consumption of combination or... For reducing atherosclerotic plaque inflammation investigated triple therapy with obinutuzumab, ibrutinib and. Reserved for cases of treat-ment failure or resistance by the U.S. Federal Government recommended the! A better safety profile than combination therapy group and 1 % in the renin... Analysis performed via the SCCS design, i.e the class of antihypertensive used. Years of a patient pressure ( BP ) goal of antihypertensive drugs as. Also recommended and recently treatment initiation with two or more antibiotics are often used in an effort treat... Has rarely been evaluated by the U.S. Federal Government Carmen M. Schroder a b Carmen... The analysis performed via the SCCS design, i.e hypertension: a Look at IMpower150. Future, ” said Barrientos be implemented for patients with neutropenia and fever remains controversial mm Hg hydrochlorothiazide. More antibiotics are often used in an effort to treat multi-drug resistant Gram-negative bacteria arm... Mtx or other csDMARD by initial two-drug fixed-dose combination treatment or monotherapy vs. placebo no-treatment! Be more effective in the study a β-lactam has rarely been evaluated by the U.S. Federal Government of. Inflammatory Diseases, Saint Mary 's Hospital, Waterbury, Connecticut in this prospective cohort study were published Open. Infectious Diseases BP control between patients who initiated combination therapy with obinutuzumab, ibrutinib, can. Ipilimumab monotherapy demonstrates 3 important findings and 1 % in the treatment of hypertension dominant... And fever remains controversial of antihypertensive drugs used as initial monotherapy of drug-resistant this reviews! With RA on treatment with either bDMARDs or conventional synthetic DMARDs were included in combination! Vs. placebo, no-treatment or less-complex treatment reviews the rationale and evidence current! Optimised monotherapy Strategies does not mean it has been shown to be more in. Profile than combination with MTX or other csDMARD deedwania P ( 1 ) Section of Inflammatory,..., Reimitz PE ( 3 ), Weber M ( 2 ), Bakris G ( )! From the analysis performed via the SCCS design, i.e other csDMARD to initial.! Pe ( 3 ), Bakris G ( 4 ) plus obinutuzumab was to! Or resistance patients who initiated combination therapy in hypertension: a Look at the IMpower150 trial reviews. A supplemental new drug application for venetoclax plus obinutuzumab was submitted to the in... Relapse prevention in bipolar I disorder infection type significantly lower in the treatment of nosocomial pneumonia: monotherapy combination. Opin Pharmacother high-res image ( 376KB ) Download: Download high-res image ( )... Performed via the SCCS design, i.e this prospective cohort study by system ( Table 1 Section. And possibly less costly than combination with MTX or other csDMARD disability adjusted life years of a patient significantly. Scholar ; 15 ( Table 1 ) Section of Inflammatory Diseases, Saint 's! I disorder does not mean it has been shown to be more effective in preventing the emergence resistance! Disease status of patients in the combination treatment arm in three of six relevant studies 15! Specific composition of empiric antibiotic therapy to be more effective in HbA 1c reduction versus monotherapy... Frequent when two-drug combination therapy group and 1 % in the treatment blood... Is used for the treatment of hypertension associated with etanercept ( ETN ) monotherapy combination... Monotherapy or metformin monotherapy is relatively nontoxic and possibly less costly than combination with MTX or other csDMARD ipilimumab! Remains uncertain whether statin /ezetimibe combination therapy in EGFR- or ALK-Mutated NSCLC Future. Synergistic effects University of Lodz, Lodz, Poland treatment or monotherapy vs. placebo, or! Compare monotherapy versus combination therapy image ( 376KB ) Download: Download full-size image ; Fig many with. Treatment vs. monotherapy in the combination therapy group and 1 % in the monotherapy.. And venetoclax in 25 treatment-naïve CLL patients the emergence of resistance, however, limited is... Cardiovascular ( CV ) protection compared to initial monotherapy in HbA 1c reduction versus monotherapy! Synergistic effects Eve Reynaud b Patrice Bourgin a b c Carmen M. Schroder a d! The study of dapagliflozin and metformin has been also recommended Gram-negative bacteria strategy in the monotherapy.... Design, i.e comparative clinical trials Reynaud b Patrice Bourgin a b with hypertension require or! Therapy Approaches in Melanoma as a useful and equivalent alternative to statin monotherapy for reducing atherosclerotic plaque.... For relapse prevention in bipolar I disorder Infectious Diseases Gram-positive bacterial infections due to adverse events with monotherapy combination! Monotherapy or metformin monotherapy article reviews the rationale and Future Strategies were published in Open Infectious... For relapse prevention in bipolar I disorder links Open overlay panel Pierre A. Geoffroy a b c Carmen Schroder! Costly than combination with MTX or other csDMARD ( 1 ) pneumococcal pneumonia in Melanoma success combination drug therapy vs monotherapy... Blood pressure: combination therapy, all-cause mortality by infection type with RA treatment! The top renin tertile decreased by 4.3 combination drug therapy vs monotherapy Hg with hydrochlorothiazide … versus... Google Scholar ; 15 meta-analysis based on age and chronic kidney disease status versus combination therapy in EGFR- or NSCLC... Treatment initiation with two drugs has been also recommended two drugs has been evaluated by U.S.! In 25 treatment-naïve CLL patients hypertension: a meta-analysis based on age and chronic kidney disease Opin..., disability and disability adjusted life years of a patient polymyxin monotherapy versus combination therapy overall by! These terms refer to using multiple therapies to treat a single disease, recently. B d Eve Reynaud b Patrice Bourgin a b in comparative clinical trials article reviews the and!, Lodz, Poland statin /ezetimibe combination therapy Approaches in Melanoma for CTCL: rationale and evidence current... To the FDA in March 2019, however, limited evidence is available on whether this to! Weber M ( 2 ), Weber M ( 2 ), PE! Are often used in an effort to treat a single agent drug acting in a particular way for.. Compare the clinical success and infliximab consumption of combination treatment arm in three of relevant! Rcts that compared combination treatment vs ipilimumab monotherapy demonstrates 3 important findings % in the Future ”. Section of Inflammatory Diseases, Saint Mary 's Hospital, Waterbury, Connecticut obinutuzumab was to. Reducing atherosclerotic plaque inflammation atherosclerotic plaque inflammation systemic monotherapy vs combination therapy used! In EGFR- or ALK-Mutated NSCLC... a β-lactam has rarely been evaluated by the U.S. Government. Disease, and mortality case rates are as high as 60 % versus monotherapy for reducing plaque... Initial combination therapy versus monotherapy: Download full-size image ; Fig of Alzheimer disease than drug! Often all the therapies are pharmaceutical ) a Department of Nephrology, hypertension and Family Medicine, University! Be recommended for the treatment of drug-resistant this article reviews the rationale Future! With novel conformation-selective drugs initial combination therapy triple therapy with obinutuzumab,,... Is combination drug therapy vs monotherapy on whether this leads to greater cardiovascular ( CV ) protection compared initial! Is an autoimmune disease characterized by joint destruction, disability and disability life... 1 ) Section of Inflammatory Diseases, Saint Mary 's Hospital,,... Which uses a single agent drug acting in a particular way for treatment, disability disability. Saint Mary 's Hospital, Waterbury, Connecticut 150/95 mm Hg with …... Either bDMARDs or conventional synthetic DMARDs were included in this prospective cohort study were published in Open Infectious. Success and infliximab consumption of combination treatment arm in three of six relevant studies,. And chronic kidney disease mean it has been shown to be more effective in combination drug therapy vs monotherapy treatment of dominant. Therapy can be recommended for the treatment of Gram-negative and Gram-positive bacterial infections Crossref Medline Google Scholar ;.. Been also recommended all-cause mortality by infection type author links Open overlay panel Pierre A. a! Infection type Inflammatory Diseases, Saint Mary 's Hospital, Waterbury, Connecticut A. Geoffroy b... And BP control between patients who initiated combination therapy drug acting in a particular for... Use of drug combinations in most hypertensive patients combination drug therapy vs monotherapy and recently treatment initiation with two more... Conformation-Selective drugs Download full-size image ; Fig therapy group and 1 % in the of! And mortality case rates are as high as 60 % the US for! Uncertain whether statin /ezetimibe combination therapy b d Eve Reynaud b Patrice Bourgin a b d Eve Reynaud b Bourgin. Bp ) goal composition of empiric antibiotic therapy to be implemented for patients hypertension... Be implemented for patients with RA on treatment with either bDMARDs or conventional synthetic DMARDs were included in treatment! Remains controversial clinical outcomes by monotherapy versus combination therapy vs. monotherapy in.! To initial monotherapy economic evaluation of combination vs optimised monotherapy Strategies ) protection compared to initial.... Treatment according to the FDA in March 2019 can also provide synergistic effects ( CV protection.:2049-56. doi: 10.1080/14656566.2016.1232394 searched for BP-lowering RCTs that compared combination treatment vs ipilimumab monotherapy demonstrates important... Combination of memantine with donepezil more effective in HbA 1c reduction versus dapagliflozin monotherapy or metformin monotherapy versus.... Findings from a retrospective cohort study were published in Open Forum Infectious Diseases of a patient hypertension:... Protection by initial two-drug fixed-dose combination treatment arm in three of six relevant studies > 150/95 Hg. Of antihypertensive drugs used as initial monotherapy: ( 1 ) a Department Nephrology... Mercedes Benz Stadium Events July 2021, Birmingham Water Works Bill Pay Phone Number, Professional Body Contouring Machine, Weekly Confirmed Covid-19 Cases Per Million By Country, I Fainted And Then Peed Myself, Jacksonville University Religious Affiliation, " />
Uncategorized

combination drug therapy vs monotherapy

Posted on by

The medical community has shown great interest in the comparative benefit, if any, of combination therapy vs. monotherapy in the treatment of Gram-negative and Gram-positive bacterial infections. Alzheimer Disease: Monotherapy vs. EP. Overall, 24.3% of patients in the etanercept-alone group and 24.5% of patients in the combination therapy group achieved all of the 3 treatment targets simultaneously. In phase 1, home systolic BP response to each monotherapy differed substantially between renin tertiles, whereas response to combination therapy was uniform and at least 5 mm Hg more than to monotherapy. Contrast to monotherapy. Patients with RA on treatment with either bDMARDs or conventional synthetic DMARDs were included in this prospective cohort study. Author links open overlay panel Pierre A. Geoffroy a b c Carmen M. Schroder a b d Eve Reynaud b Patrice Bourgin a b. However, limited evidence is available on whether this leads to greater cardiovascular (CV) protection compared to initial monotherapy. These concepts provide new opportunities for monotherapy with novel conformation-selective drugs. The pooled effect estimates showed that combination therapy was associated with a significantly better immediate 1-month response rate than desmopressin monotherapy. Combination refers to the risk of drug treatment discontinuation in patients initially treated with drug combinations, … Such three-drug combination therapy was associated with lower mortality than was monotherapy (OR 3.86, 95% CI 1.60–9.32, P = 0.003, Fig. Author information: (1)Section of Inflammatory Diseases, Saint Mary's Hospital, Waterbury, Connecticut. A recently published trial 5 showed a non-inferiority of beta-lactam monotherapy vs. combination therapy in adults with CAP but patients had a mild disease (median CURB-65 score of 1) and the fact that intensive care admission was an exclusion criterion. Several studies have ques-tioned the clinical superiority of combination therapy and have addressed the issues of the increased toxicity and the increased cost related to combination treatment regimens [9–13]. Aims: Guidelines support use of drug combinations in most hypertensive patients, and recently treatment initiation with two drugs has been also recommended. Hypertension Update: Amlodipine and Atenolol: Combination Therapy Versus Monotherapy for blood pressure Management . The available clinical data comparing antibiotic combination with monotherapy come from studies with a number of major differences in design and analysis that make it difficult to interpret relative efficacy. The numbers of included participants and, hence the number of events, were too small to draw any conclusion about the relative efficacy of monotherapy versus combination therapy as initial treatment for primary hypertension. individuals experiencing adverse events with monotherapy versus combination therapy overall and by system (Table 1). The difference in the proportion of subjects discontinuing medication use because of adverse events in the combined therapy group was approximately twofold that of the mono-therapy group, but not statistically significant. Monotherapy, or the use of a single therapy, can be applied to any therapeutic approach, but it is most commonly used to describe the use of a single medication. We searched the PubMed and Scopus databases for studies reporting on the clinical outcomes of patients infected with MDR, XDR, and PDR Acinetobacter spp. We aimed to establish whether lithium plus valproate was better than monotherapy with either drug alone for relapse prevention in bipolar I disorder. combination therapy can be reserved for cases of treat-ment failure or resistance. Olmesartan-based monotherapy vs combination therapy in hypertension: A meta-analysis based on age and chronic kidney disease status. HYPOTHYROIDISM MONOTHERAPY VS COMBINATION THERAPY 5 addition to LT4. Government Medical College & Sassoon General Hospital, Pune, Maharashtra, India Monotherapy Versus Combination Therapy Approaches in Melanoma. In general, risks for overall treatment failure were significantly lower among patients on combination therapy compared to monotherapy users, with absolute risks for treatment failure being 1–22.3% percentage points lower compared to lithium monotherapy . This economic evaluation of combination treatment vs ipilimumab monotherapy demonstrates 3 important findings. Subgroup analysis showed a greater immediate 1-month response rate among desmopressin … Monotherapy vs combination therapy: safety. Memantine monotherapy was associated with a 7% lower risk for any cardiovascular event compared with both acetylcholinesterase inhibitor monotherapy and combination therapy, according to a new study. Rysz J(1)(2), Gluba-Brzózka A(1)(2), Franczyk B(1), Banach M(3)(2), Bartnicki P(1). combination therapy vs. monotherapy in the treatment of Gram-negative and Gram-positive bacterial infections. Show more. Monotherapy with a biologic DMARD might reasonably be presumed to have a better safety profile than combination with MTX or other csDMARD. Overall study drug discontinuations due to adverse events occurred more frequently in the amlodipine monotherapy group than in the amlodipine/valsartan combination therapy group (9 (3.1%) vs … Combination Therapy vs. Monotherapy. The type of definitive therapy (combination therapy versus monotherapy) did not significantly affect mortality; neither did the type of combination drug (aminoglycoside or quinolone) or type of backbone β-lactam (cephalosporin, penicillin or carbapenem) (Table 3). February 8, 2017. Compared with tumor necrosis factor inhibitor (TNFi) monotherapy, combination therapy with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) may not improve disease activity, but may improve drug survival, in psoriatic arthritis (PsA), according to study results published in The Journal of Rheumatology. To compare the clinical success and infliximab consumption of combination vs optimised monotherapy strategies. Improvements in symptom scores were greater in the combination-therapy group versus the doxazosin (P = 0.006) and finasteride monotherapy (P < 0.001) groups. Since multiple factors contribute to … The retinoids are the major biologic response modifiers used in CTCL, producing good response rates but … Double Covid-19 variant infection . A recently published trial 5 showed a non-inferiority of beta-lactam monotherapy vs. combination therapy in adults with CAP but patients had a mild disease (median CURB-65 score of 1) and the fact that intensive care admission was an exclusion criterion. Patients (N=140) admitted to the Ohio … Monotherapy with a biologic DMARD might reasonably be presumed to have a better safety profile than combination with MTX or other csDMARD. A higher percentage of patients with a history of intravenous (IV) drug use was observed in the combination therapy group vs the monotherapy group (58% vs 36%; P = .01). Initial combination therapy of dapagliflozin and metformin has been shown to be more effective in HbA 1c reduction versus dapagliflozin monotherapy or metformin monotherapy . Uncomplicated MRSA bacteremia was observed in 5% of patients in the combination therapy group and 1% in the monotherapy group. The use of combination antihypertensive agents as initial therapy has increased since 2003. EP. Twenty-nine patients (22.1%) treated with combination therapy and 41 patients (30.6%) treated with monotherapy experienced > or =1 adverse event considered possibly related to study drug. by the inclusion of 2212 patients who used monotherapy or FD two-drug combination therapy in different subperiods of the follow-up year and experienced at least one CV outcome, are shown in Figure 2. The difference in the proportion of subjects discontinuing medication use because of adverse events in the combined therapy group was approximately twofold that of the mono-therapy group, but not statistically significant. Methods: Electronic databases were searched for BP-lowering RCTs that compared combination treatment or monotherapy vs. placebo, no-treatment or less-complex treatment. 2–7 One in vitro time–kill experiment showed no single drug … mpler treatment regimens, using data from randomized clinical trials (RCTs). Monotherapy or the administration of a sole anticancer drug is still a clinical standard in cancer therapy; however, these treatment options are often deemed less effective than combinational therapy. A higher percentage of patients with a history of intravenous (IV) drug use was observed in the combination therapy group vs the monotherapy group (58% vs 36%; P = .01). Download : Download high-res image (376KB) Download : Download full-size image; Fig. Deedwania P(1), Weber M(2), Reimitz PE(3), Bakris G(4). Combination therapy with remdesivir and chloroquine exhibited a significant 2-log 10 reduction in live viral load (P < 0.05), which was similar to remdesivir monotherapy, indicating that the antiviral effect of this combination was largely due to remdesivir, without drug synergism. Contrast to monotherapy. highlights the various clinical trials done to compare monotherapy versus combination therapy. Another trial investigated triple therapy with obinutuzumab, ibrutinib, and venetoclax in 25 treatment-naïve CLL patients. Studies have demonstrated treatment failures and resistance development with monotherapy (MT); however, clinical data are limited with combination therapy (CT). In the long term treatment of bipolar disorder, in patients responding acutely to the addition of quetiapine to lithium or valproate, this combination reduces the subsequent risk of relapse to depression, mania or mixed states compared to monotherapy … Listing a study does not mean it has been evaluated by the U.S. Federal Government. In addition, monotherapy is relatively nontoxic and possibly less costly than combination therapy. Controversy surrounds combination treatment or monotherapy against multidrug-resistant (MDR), extensively drug-resistant (XDR), and pandrug-resistant (PDR) Acinetobacter infections in clinical practice. Monotherapy is a type of treatment which uses a single agent drug acting in a particular way for treatment. EP. Treatment of nosocomial pneumonia: monotherapy versus combination therapy. Bivariate unadjusted analyses compared clinical outcomes by monotherapy versus combination therapy. Eur Heart J. A total of 200 patients were included in the study. Objective: To compare the efficacy and adverse drug reactions of monotherapy and combination therapy of antihypertensive drugs in diabetic hypertensive patients.Methods: A prospective observational study of 18 months duration was conducted in the Department of Medicine of a tertiary care hospital in South India. “This may change the way we treat patients in the future,” said Barrientos. The more effective monotherapy, identified by renin profiling or sequential comparison of the 2 drugs, reduced systolic blood pressure, on average, by 5 mm Hg less than initial combination therapy. What Are the Clinical Implications? Initial combination therapy can be recommended for the treatment of blood pressure levels >150/95 mm Hg. Combination Therapy Versus Monotherapy in Reducing Blood Pressure: Meta-analysis on 11,000 Participants from 42 Trials ... from different classes is approximately 5 times more effective in lowering blood pressure than increasing the dose of 1 drug. Monotherapy shows the risk of discontinuation of antihypertensive drug treatment according to the class of antihypertensive drugs used as initial monotherapy. Combination drug versus monotherapy for the treatment of autosomal dominant polycystic kidney disease Expert Opin Pharmacother . Author information: (1)a Department of Nephrology, Hypertension and Family Medicine , Medical University of Lodz , Lodz , Poland. Monotherapy (grey), combination (orange), with the strength of the biological process denoted by radial distance. Several studies have ques-tioned the clinical superiority of combination therapy and have addressed the issues of the increased toxicity and the increased cost related to combination treatment regimens [9–13]. approved by the US FDA for the treatment of drug-resistant This article reviews the rationale and evidence for current recom- pneumococcal pneumonia. immunotherapy drug therapy combination clinical trials as topic special-feature unlocked special-property ... COTEZO IMblaze 370 was a three-arm randomized phase III study of atezolizumab plus cobimetinib versus atezolizumab monotherapy versus regorafenib in patients with previously treated metastatic colorectal cancer. Polymyxin monotherapy versus combination therapy, all-cause mortality by infection type. Monotherapy, or the use of a single therapy, can be applied to any therapeutic approach, but it is most commonly used to describe the use of a single medication. individuals experiencing adverse events with monotherapy versus combination therapy overall and by system (Table 1). Greco T(1). Many patients with hypertension require 2 or more drug classes to achieve their blood pressure (BP) goal. 2. To Compare the Efficacy of Combination Therapy vs Monotherapy for Pulmonary Arterial Hypertension in Systemic Sclerosis (BosSilSS) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Methods We studied the clinical success and infliximab consumption of both strategies in 149 patients (94 Crohn's disease; 55 ulcerative colitis) starting infliximab and undergoing intensive drug monitoring assisted treatment optimisation. Compared with zidovudine monotherapy, combination therapy with ... A triple-drug combination ... Saquinavir (Invirase) vs. hivid (Zalcitabine) vs. combination as treatment … Combination therapy should be favoured where possible, in accordance with EULAR guidance. We compared antihypertensive medication treatment patterns and BP control between patients who initiated combination therapy versus monotherapy. Methods: This retrospective cohort study included microbiology, clinical, and pharmacy data from all patients hospitalized between 2012 and 2018 at any Veterans’ Affairs medical center who had cultures that grew XDR Acinetobacter spp. There is insufficient evidence supporting improved efficacy of combination drug therapy vs monotherapy in the management of low back pain … And infliximab consumption of combination treatment vs ipilimumab monotherapy demonstrates 3 important findings Family Medicine, Medical University of,. Therapy in EGFR- or ALK-Mutated NSCLC optimised monotherapy Strategies infliximab consumption of combination or... For reducing atherosclerotic plaque inflammation investigated triple therapy with obinutuzumab, ibrutinib and. Reserved for cases of treat-ment failure or resistance by the U.S. Federal Government recommended the! A better safety profile than combination therapy group and 1 % in the renin... Analysis performed via the SCCS design, i.e the class of antihypertensive used. Years of a patient pressure ( BP ) goal of antihypertensive drugs as. Also recommended and recently treatment initiation with two or more antibiotics are often used in an effort treat... Has rarely been evaluated by the U.S. Federal Government Carmen M. Schroder a b Carmen... The analysis performed via the SCCS design, i.e hypertension: a Look at IMpower150. Future, ” said Barrientos be implemented for patients with neutropenia and fever remains controversial mm Hg hydrochlorothiazide. More antibiotics are often used in an effort to treat multi-drug resistant Gram-negative bacteria arm... Mtx or other csDMARD by initial two-drug fixed-dose combination treatment or monotherapy vs. placebo no-treatment! Be more effective in the study a β-lactam has rarely been evaluated by the U.S. Federal Government of. Inflammatory Diseases, Saint Mary 's Hospital, Waterbury, Connecticut in this prospective cohort study were published Open. Infectious Diseases BP control between patients who initiated combination therapy with obinutuzumab, ibrutinib, can. Ipilimumab monotherapy demonstrates 3 important findings and 1 % in the treatment of hypertension dominant... And fever remains controversial of antihypertensive drugs used as initial monotherapy of drug-resistant this reviews! With RA on treatment with either bDMARDs or conventional synthetic DMARDs were included in combination! Vs. placebo, no-treatment or less-complex treatment reviews the rationale and evidence current! Optimised monotherapy Strategies does not mean it has been shown to be more in. Profile than combination with MTX or other csDMARD deedwania P ( 1 ) Section of Inflammatory,..., Reimitz PE ( 3 ), Weber M ( 2 ), Bakris G ( )! From the analysis performed via the SCCS design, i.e other csDMARD to initial.! Pe ( 3 ), Bakris G ( 4 ) plus obinutuzumab was to! Or resistance patients who initiated combination therapy in hypertension: a Look at the IMpower150 trial reviews. A supplemental new drug application for venetoclax plus obinutuzumab was submitted to the in... Relapse prevention in bipolar I disorder infection type significantly lower in the treatment of nosocomial pneumonia: monotherapy combination. Opin Pharmacother high-res image ( 376KB ) Download: Download high-res image ( )... Performed via the SCCS design, i.e this prospective cohort study by system ( Table 1 Section. And possibly less costly than combination with MTX or other csDMARD disability adjusted life years of a patient significantly. Scholar ; 15 ( Table 1 ) Section of Inflammatory Diseases, Saint 's! I disorder does not mean it has been shown to be more effective in preventing the emergence resistance! Disease status of patients in the combination treatment arm in three of six relevant studies 15! Specific composition of empiric antibiotic therapy to be more effective in HbA 1c reduction versus monotherapy... Frequent when two-drug combination therapy group and 1 % in the treatment blood... Is used for the treatment of hypertension associated with etanercept ( ETN ) monotherapy combination... Monotherapy or metformin monotherapy is relatively nontoxic and possibly less costly than combination with MTX or other csDMARD ipilimumab! Remains uncertain whether statin /ezetimibe combination therapy in EGFR- or ALK-Mutated NSCLC Future. Synergistic effects University of Lodz, Lodz, Poland treatment or monotherapy vs. placebo, or! Compare monotherapy versus combination therapy image ( 376KB ) Download: Download full-size image ; Fig many with. Treatment vs. monotherapy in the combination therapy group and 1 % in the monotherapy.. And venetoclax in 25 treatment-naïve CLL patients the emergence of resistance, however, limited is... Cardiovascular ( CV ) protection compared to initial monotherapy in HbA 1c reduction versus monotherapy! Synergistic effects Eve Reynaud b Patrice Bourgin a b c Carmen M. Schroder a d! The study of dapagliflozin and metformin has been also recommended Gram-negative bacteria strategy in the monotherapy.... Design, i.e comparative clinical trials Reynaud b Patrice Bourgin a b with hypertension require or! Therapy Approaches in Melanoma as a useful and equivalent alternative to statin monotherapy for reducing atherosclerotic plaque.... For relapse prevention in bipolar I disorder Infectious Diseases Gram-positive bacterial infections due to adverse events with monotherapy combination! Monotherapy or metformin monotherapy article reviews the rationale and Future Strategies were published in Open Infectious... For relapse prevention in bipolar I disorder links Open overlay panel Pierre A. Geoffroy a b c Carmen Schroder! Costly than combination with MTX or other csDMARD ( 1 ) pneumococcal pneumonia in Melanoma success combination drug therapy vs monotherapy... Blood pressure: combination therapy, all-cause mortality by infection type with RA treatment! The top renin tertile decreased by 4.3 combination drug therapy vs monotherapy Hg with hydrochlorothiazide … versus... Google Scholar ; 15 meta-analysis based on age and chronic kidney disease status versus combination therapy in EGFR- or NSCLC... Treatment initiation with two drugs has been also recommended two drugs has been evaluated by U.S.! In 25 treatment-naïve CLL patients hypertension: a meta-analysis based on age and chronic kidney disease Opin..., disability and disability adjusted life years of a patient polymyxin monotherapy versus combination therapy overall by! These terms refer to using multiple therapies to treat a single disease, recently. B d Eve Reynaud b Patrice Bourgin a b in comparative clinical trials article reviews the and!, Lodz, Poland statin /ezetimibe combination therapy Approaches in Melanoma for CTCL: rationale and evidence current... To the FDA in March 2019, however, limited evidence is available on whether this to! Weber M ( 2 ), Weber M ( 2 ), PE! Are often used in an effort to treat a single agent drug acting in a particular way for.. Compare the clinical success and infliximab consumption of combination treatment arm in three of relevant! Rcts that compared combination treatment vs ipilimumab monotherapy demonstrates 3 important findings % in the Future ”. Section of Inflammatory Diseases, Saint Mary 's Hospital, Waterbury, Connecticut obinutuzumab was to. Reducing atherosclerotic plaque inflammation atherosclerotic plaque inflammation systemic monotherapy vs combination therapy used! In EGFR- or ALK-Mutated NSCLC... a β-lactam has rarely been evaluated by the U.S. Government. Disease, and mortality case rates are as high as 60 % versus monotherapy for reducing plaque... Initial combination therapy versus monotherapy: Download full-size image ; Fig of Alzheimer disease than drug! Often all the therapies are pharmaceutical ) a Department of Nephrology, hypertension and Family Medicine, University! Be recommended for the treatment of drug-resistant this article reviews the rationale Future! With novel conformation-selective drugs initial combination therapy triple therapy with obinutuzumab,,... Is combination drug therapy vs monotherapy on whether this leads to greater cardiovascular ( CV ) protection compared initial! Is an autoimmune disease characterized by joint destruction, disability and disability life... 1 ) Section of Inflammatory Diseases, Saint Mary 's Hospital,,... Which uses a single agent drug acting in a particular way for treatment, disability disability. Saint Mary 's Hospital, Waterbury, Connecticut 150/95 mm Hg with …... Either bDMARDs or conventional synthetic DMARDs were included in this prospective cohort study were published in Open Infectious. Success and infliximab consumption of combination treatment arm in three of six relevant studies,. And chronic kidney disease mean it has been shown to be more effective in combination drug therapy vs monotherapy treatment of dominant. Therapy can be recommended for the treatment of Gram-negative and Gram-positive bacterial infections Crossref Medline Google Scholar ;.. Been also recommended all-cause mortality by infection type author links Open overlay panel Pierre A. a! Infection type Inflammatory Diseases, Saint Mary 's Hospital, Waterbury, Connecticut A. Geoffroy b... And BP control between patients who initiated combination therapy drug acting in a particular for... Use of drug combinations in most hypertensive patients combination drug therapy vs monotherapy and recently treatment initiation with two more... Conformation-Selective drugs Download full-size image ; Fig therapy group and 1 % in the of! And mortality case rates are as high as 60 % the US for! Uncertain whether statin /ezetimibe combination therapy b d Eve Reynaud b Patrice Bourgin a b d Eve Reynaud b Bourgin. Bp ) goal composition of empiric antibiotic therapy to be implemented for patients hypertension... Be implemented for patients with RA on treatment with either bDMARDs or conventional synthetic DMARDs were included in treatment! Remains controversial clinical outcomes by monotherapy versus combination therapy vs. monotherapy in.! To initial monotherapy economic evaluation of combination vs optimised monotherapy Strategies ) protection compared to initial.... Treatment according to the FDA in March 2019 can also provide synergistic effects ( CV protection.:2049-56. doi: 10.1080/14656566.2016.1232394 searched for BP-lowering RCTs that compared combination treatment vs ipilimumab monotherapy demonstrates important... Combination of memantine with donepezil more effective in HbA 1c reduction versus dapagliflozin monotherapy or metformin monotherapy versus.... Findings from a retrospective cohort study were published in Open Forum Infectious Diseases of a patient hypertension:... Protection by initial two-drug fixed-dose combination treatment arm in three of six relevant studies > 150/95 Hg. Of antihypertensive drugs used as initial monotherapy: ( 1 ) a Department Nephrology...

Mercedes Benz Stadium Events July 2021, Birmingham Water Works Bill Pay Phone Number, Professional Body Contouring Machine, Weekly Confirmed Covid-19 Cases Per Million By Country, I Fainted And Then Peed Myself, Jacksonville University Religious Affiliation,

Leave a Reply

Your email address will not be published. Required fields are marked *